Speakers

Sleep and Pain from Research to Reality AACP Australian Chapter - 6th International Symposium Sydney, Friday March 17th –Sunday March 19th 2017

Gregory Neely

GREG NEELY


Greg is the Head of Functional Genomics, Neuroscience Division at the Garvan Institute of Medical Research, and a NHMRC CDF Fellow, and Associate Professor at the University of Sydney
At the Garvan Institute Greg employs a functional genomics approach, complemented with bioinformatics analysis, to find and characterize novel conserved genes participating in human diseases. He has a primary focus on the conserved genomics of chronic pain perception. More recently he has initiated similar projects targeting lifespan extension, or preventing neurological diseases that increase with age including age-related dementia, Alzheimer's disease, Parkinson's disease and ALS. His work has helped to identify and validate novel human disease genes and discover new potential therapies. Greg is1 of 7 board of governors for the pain genetics SAG of the International Association for the Study of Pain the major international organization devoted to pain research, and acts as an external reviewer for multiple journals (Neuron, Pain, Journal of Immunology, Nature Methods, Current Biology etc.) and granting agencies, and is an invited member of the Australian federal NHMRC assigners academy and the CIHR panel on High Fatality Cancers.

Gilles Lavigne

GILLES LAVIGNE


Gilles received a Doctor honoris causa from the University of Zurich, Switzerland. He holds a Canada Research Chair in Pain, Sleep & Trauma.
Gilles was Dean of the Faculty of Dental Medicine at the Université de Montréal, Canada (2008-2016). He was President of the Canadian Sleep Society and President of the Canadian Pain Society (2014–2016). He is co-founder and past Director of the three research networks for Oral Health, Pain and Placebo Mechanisms under the Fonds de la Recherche en Santé du Quebec and the Canadian Institutes of Health Research (CIHR). He is internationally recognized for his experimental and clinical research projects on sleep bruxism and the interactions between sleep, pain, and breathing disorders. He is a Researcher at the Pain and Sleep Laboratory, Trauma axis, Surgery department, Hôpital du Sacré-Cœur de Montréal. Current studies include 1) the role of sleep in placebo analgesia and pain relief expectations in emergency medicine, 2) the influence of opioids on sleep airway function and addiction, and 3) sleep and pain interactions in traumatic brain injury patients.

David Gozal

DAVID GOZAL


Dr. Gozal is currently the Herbert T. Abelson Professor at the University of Chicago, where he also holds the title of Pritzker Scholar. He received his M.D. from the Hebrew University of Jerusalem, completed his pediatric residency at the Haifa Medical Center in Israel, and then spent 2 years in Cameroon, West Africa, developing rural healthcare networks, for which he received the title of "Knight of the Order of Merit". He then completed his pediatric pulmonology and sleep medicine training at Childrens Hospital Los Angeles in 1993.
Dr Gozal's research interests emphasize bench to bedside approaches to pediatric sleep disorders, with projects encompassing a wide range of interests, such as gene and cellular regulation in hypoxia and sleep disruption, murine models of sleep disorders, and genomic and proteomic approaches to clinical and epidemiological aspects of sleep in children, including collaborative work in several countries around the world. David will become President of the American Thoracic Society in May of 2016, and was awarded the William C. Dement Academic Achievement Award by the American Academy of Sleep Medicine in 2013 and the 2016 Lifetime Achievement Award of the National Sleep Foundation.

Stephan Schug

STEPHAN SCHUG


Stephan Schug is Professor and Chair of Anaesthesiology in the Department of Pharmacology, Pharmacy and Anaesthesiology of the University of Western Australia, and Director of Pain Medicine at Royal Perth Hospital. His principal research interests include the management of acute and chronic pain, cancer pain, regional anaesthesia, the pharmacology of local anaesthetics and analgesics and quality improvement in health care. Professor Schug studied medicine and clinical pharmacology at the University of Cologne, Germany, and subsequently specialised in anaesthesia and pain medicine. Professor Schug is an active member of several pain and anaesthesia societies including Vice-Chair of the SIG Acute Pain of IASP and Chair of the SIG Acute Pain of ACE, is a Fellow of the Australian and New Zealand College of Anaesthetists (ANZCA) and its Faculty of Pain Medicine (FPMANZCA).

Leila Kheirandish-gozal

LEILA KHEIRANDISH-GOZAL


Leila is the Professor Director of Clinical Sleep Research Section of Pediatric Sleep Medicine Department of Pediatrics, The University of Chicago. She has a Bachelor Degree in Arabic Literature with Honors, from the Foreign Language Institute, Damascus, Syria, and attended Medical School at the University of Damascus, Syria, where she was awarded Doctor of Medicine.
She holds a Master of Science in Epidemiology and Clinical Investigation Sciences, from the School of Public Health, the University of Louisville, KY, and Professional Certification in Translational Medicine from the European Society for Translational Medicine. In 2014 she became Professor of Pediatrics and Director of Clinical Sleep Research, Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago., Department of Pediatrics, University of Chicago, IL.

Peter Cistulli

PETER CISTULLI


Peter Cistulli is the ResMed Chair in Sleep Medicine at the University of Sydney. He is an active clinician researcher with 25 years experience in respiratory and sleep medicine and is head of the Centre for Sleep Health & Research in the Department of Respiratory and Sleep Medicine at Royal North Shore Hospital. His research has focussed on the pathophysiology of Obstructive Sleep Apnea and novel therapeutic approaches. This work has been predominantly funded by the NHMRC of Australia. He has an extensive publication record, and has received international awards for his academic contributions to the sleep field. He is a former President of the Australasian Sleep Association. He currently serves on the board of directors of the Sleep Health Foundation (Australia), whose mission is to raise community and government awareness of the negative impact of untreated sleep disorders and poor sleep practices on health, safety, productivity and quality of life.

DELWYN BARTLETT

DELWYN BARTLETT


Associate Professor Delwyn Bartlett is a Health Psychologist and Coordinator of the Medical Psychology, Sleep and Circadian Group at the Woolcock Institute of Medical Research. She graduated in Psychology from Macquarie University and completed her PhD in neurobehavioural and neurobiological effects of sleep apnea at the University of Sydney. Delwyn has a strong interest in behavioural management of insomnia and adherence to CPAP use and currently is part of a Health Coaching intervention. She is currently involved in research exploring the role of a sleep intervention to reduce the risk of post-natal depression, and a cognitive behavioural therapy intervention to improve sleep in older adults who are mildly cognitively impaired.

Tasha Stanton

TASHA STANTON


Dr Tasha Stanton is a Senior Research Fellow at The University of South Australia, Adelaide and Neuroscience Research Australia, Sydney. Dr Stanton currently holds an NHRMC Early Career Fellowship (2014-2018). She has received >$1.7m in competitive research funding and has been a keynote/invited speaker at 20 national and international conferences. Her research focusses on clinical pain neuroscience, with a specific interest in cortical body representation, somatosensation, multi-modal illusions, and pain. In February 2016 Dr Stanton was announced as the Ronald Dubner Research Prize Winner for 2016. This award has honoured the best clinical or basic science research paper, series of papers, or doctoral thesis in the field of pain.

Mark Hutchinson

MARK HUTCHINSON


Professor Hutchinson is an ARC Australian Research Fellow and is the Director of the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP). He is also a Professor within the School of Medicine at the University of Adelaide. Professor Hutchinson returned to the University of Adelaide in 2009 as an NHMRC CJ Martin Research Fellow, and established the Neuroimmunopharmacology research laboratory.
From 2005 to 2009 Mark worked in the world leading laboratory of Prof Linda Watkins in the Center for Neuroscience at the University of Colorado at Boulder. Here he pioneered with Prof Watkins the research which has led to the discovery of novel drug activity at innate immune receptors. Mark's research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments. His work has enabled the translation of compounds at the lab bench to clinical agents used at the bedside.
Mark has published over 100 papers in journals and refereed conference proceedings. He has now added Director of the CNBP to his roles. The CNBP is an ARC Centre of Excellence with $40M of funding committed for 7 years, headquartered at The University of Adelaide, with nodes at Macquarie University, Sydney and the RMIT, Melbourne. We are partnered with universities and companies in Europe, the US and China, as well as other Australian institutions. The CNBP has a mission to "Discover new approaches to measure nano-scale dynamic phenomena in living systems".

Glenn King

GLENN KING

Glenn did his PhD at the University of Sydney before postdoctoral studies at the University of Oxford. After academic stints at the University of Sydney and the University of Connecticut Health Center, he joined the Institute for Molecular Bioscience at The University of Queensland in 2007, where he is currently a NHMRC Principal Research Fellow. The focus of Glenn's research is venoms-based drug discovery, in particular the development of novel analgesics based on venom peptides that modulate the activity of either ligand- or voltage-gated ion channels in sensory neurons. Several molecules discovered in his lab have progressed to preclinical studies.
Glenn has published over 200 journal articles and book chapters. He currently serves on the Scientific Advisory Board of three companies and the Editorial Board of four journals. Recent awards include the Sir Bob Robertson Award from the Australian Society for Biophysics (2013), the Beckman Coulter Discovery Science Award from the Australian Society for Biochemistry & Molecular Biology (2013), and the ANZMAG Medal from the Australian & New Zealand Society for Magnetic Resonance (2015).

Chris Peck

CHRIS PECK


Professor Chris Peck is Dean of the Faculty of Dentistry, the University of Sydney and President of the Australian and New Zealand Academy of Orofacial Pain. Professor Peck manages complex orofacial pain and disorder patients and conducts research on biomechanical aspects of jaw function, evidence-based diagnosis and management of orofacial pain, and biopsychosocial contributors to pain perception and jaw dysfunction. A strong advocate for multidisciplinary patient management, he is internationally renowned for his leadership and contributions to translational research in orofacial pain and leading the clinical arm of projects involving researchers from biomedicine to mathematics. He is a senior facial pain expert in the NSW public health care system at the Royal North Shore Hospital's Pain Management Research Institute, involved in patient care, clinical supervision and research. Professor Peck is President-elect of the International Research Diagnostic Criteria for Temporomandibular Disorders Consortium Network, which develops reliable and valid diagnostic criteria for facial pain complaints. Other clinical pain research groups have emulated this consortium model. Additionally, he chaired an expert International Working Group to expand the taxonomy of temporomandibular disorders (Journal of Oral Rehabilitation 2014).

Luke Henderson

LUKE HENDERSON


Dr Luke Henderson is an Associate Professor in the Sydney Medical School at the University of Sydney, Australia. For the past 15 years, Dr Henderson has led the Neural Imaging Laboratory which uses human brain imaging techniques such as functional, structural and biochemical MRI and electroencephalogram recordings to explore central changes associated with acute and chronic pain. Dr Henderson’s is currently exploring the brainstem sites responsible for endogenous analgesia, as well as the mechanisms underlying altered thalamocortical rhythm in individuals with chronic neuropathic pain.

Pete Svensson

PETER SVENSSON


Peter was born in Aalborg 1963. He graduated from the School of Dentistry, University of Aarhus 1987 (DDS), and earned his Ph.D. degree in 1993 and Doctor of Odontology in 2000 at University of Aarhus. He had a Post-doc stay at the University of Michigan from 1995-1996, and was a visiting scientist University of Adelaide 2000, a visiting professor University of British Columbia 2007, visiting professor University of Sydney 2009, Professor and chairman of Department of Clinical Oral Physiology 2001.
He was appointed clinical consultant at the Department of Oral Maxillofacial Surgery, Aarhus University Hospital in 2002 and consultant at the Danish Headache Center, University of Copenhagen in 2005. He was appointed honorary adjunct professor at Aalborg University from 2005-2010, Adjunct professor at the Center for Functionally Integrative Neuroscience 2009-2013 and visiting professor and honorary director of Sino-Denmark Orofacial Pain and TMD Research Center at Nanjing Medical University 2011-2017.
He was Knighted by Queen Ridder af Dannebrog 2011.Honorary doctor (odont.Dr.h.c) Malmø University 2013. Appointed guest professor Department of Dental Medicine, Karolinska Institutet (2014-2017).
Peter's research has focused on orofacial pain mechanisms, trigeminal physiology, brain imaging and temporomandibular disorders. He was awarded the Codan Young Investigator Research Prize in 1995, the Strathmann Research Award in 1998 and the Zendium-Hoogendoorn Award in 2000, Bagger-Soerensen Grant 2004, and Ingeborg and Leo Dannin Award 2012. In 2014 he was presented the prestigious Bagger-Soerensen Senior Research Prize and the IADR Neuroscience Senior Investigator Research Award 2015. He is an editorial board member and reviewer for several international dental and neuroscience journals including Pain and the Journal of Orofacial Pain. He is Editor-in-Chief of Journal of Oral Rehabilitation (2004-present) and Co-editor of the Textbook on Clinical Oral Physiology, Quintessence 2004. Guest editor Cephalagia in a special issue on Facial Pain (2016). He has supervised many Ph.D projects, and is Pastpresident of the Special Interest Group on Orofacial Pain, International Association for the Study of Pain (IASP) (2008-2010), President of the International Consortium of Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), and the International Association for Dental Research (IADR) (2010- 2012). Member of IASP classification task force (2014-2018).


Brett Graham

Brett Graham


Brett Graham graduated from the Univeristy of Newcastle with a Bachelor of Biomedical Sciences, and completed his his PhD in 2006, and after a short postdoctoral period started his research laboratory, now the Spinal Cord Connections Group, in 2008. The primary theme of his research is spinal sensory coding, a topic he has been focused on since completing Honours year studying inhibitory synaptic transmission between spinal dorsal horn neurons in 2001.

Using transgenic mice for a circuit-based analysis of spinal signalling, arousal and sleep in pain conditions.
One of the significant challenges to be faced as we try to improve our treatment of many pathological pain conditions is the multitude of nerve cell types that participate in pain signalling.
Specifically, depending on the nerve cell type, it may be appropriate to reduce signalling, but in other cases, we may wish to enhance signalling. Thus, the ability to identify different never cell types throughout the pain pathway is critical. Fortunately, this challenge is now being met by the use of transgenic mice that allow specific nerve cell populations to be labelled (using green fluorescent protein expression), and activated (using channelrhodopsin-2 expression - optogenetics). In this presentation I will describe recent studies that have employed these approaches to study a population of excitatory spinal nerve cells that appear to have the capacity to amplify pain signals in the spinal cord. In addition, I will present data showing the a small population of nerve cells located in lateral hypothalamus represent a link between pathological pain conditions such as neuropathic pain, sleep, and arousal. Together, this circuit-based analysis of pain pathways is revealing new targets for future pain therapies.